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Article Type

Original Study

Abstract

Objective The aim of this study was to evaluate the association between vitamin D receptor (VDR) (BsmI) gene polymorphism and genetic susceptibility to type 2 diabetes mellitus (T2DM) in an Egyptian population. Background The VDR gene is a candidate gene for susceptibility to several diseases. Studies on the association between VDR polymorphisms and T2DM in different ethnic populations are yet inconclusive. Patient and methods The present study was a case–control study conducted at the Department of Clinical Pathology, College of Medicine, Menoufia University, during the period from May 2015 to December 2016. We included 120 patients, who were divided into two groups: group A included 40 healthy patients, which served as the control group, and group B included 80 T2DM patients. Participants were subjected to the following: complete history taking and clinical examination, assessment of BMI, fasting blood sugar, 2-h postprandial, glycated haemoglobin, and lipid profile, renal function tests and PCR-restriction fragment length polymorphism for determining the genotype of BsmI gene polymorphism. Results Genotype distribution and allele frequencies of the VDR gene polymorphism differed significantly between patients and controls. The Bb genotype was higher in the T2DM group (42.5%) than in the control group (12.5%), and the bb genotype was higher in the T2DM group (7.5%) than in the control group (5%), but without statistical significance. The b allele was higher in the T2DM group (28.8%) than in the control group (11.3%). The Bb allele was found to be more risky than the BB allele by 5.610 [confidence interval (CI)=1.97–15.96], whereas the bb allele was found to be more risky than the BB allele by 2.475 (CI = 0.46–13.09). The b allele was found to be more risky than the B allele by 3.18 (CI = 1.47–6.90). Conclusion Our data suggest that VDR (BsmI) gene polymorphism genotype is associated with the risk of T2DM

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