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Article Type

Original Study

Abstract

Objective The aim of this study was to investigate the paraoxonase 1 (PON-1) activity, which is accepted as a marker of atherosclerosis, in serum of patients with subclinical hypothyroidism (SCH). Background There is now strong evidence that PON-1 plays an important role in lipoprotein metabolism and thus may affect the risk of atherosclerosis in the general population. SCH and its correlation with the atherosclerosis and atherosclerotic cardiovascular diseases is a subject of debate. Patient and methods This study included 40 young patients (<43 years old) from Menoufia University hospitals after exclusion of all known cardiovascular risk factors. They were classified into two groups: group I, healthy controls group (20 patients) and group II, patients with SCH (20 patients). All patients were subjected to thorough history taking, complete physical examination, thyroid function tests, lipid profile, and PON-1 activity. Results The mean of PON-1 activity was highly significant higher in group II than control, and there are a significant negative correlation between PON-1 activity and thyroid-stimulating hormone. SCH group was more dyslipidemic as evidenced by decreased high-density lipoprotein and increased total cholesterol, triglycerides, and low-density lipoprotein. Conclusion This study suggests that SCH is an independent risk factor for atherosclerosis, and the higher the thyroid-stimulating hormone level and the lower the PON-1 activity, hence the higher the atherosclerotic cardiovascular risk.

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