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Article Type

Original Study

Abstract

Objective The present study aimed to assess the prevalence of different Candida spp. as a cause of infections in the urinary tract infection (UTI) among catheterized patients and to test the susceptibility of Candida isolate to antifungal agents. Background UTIs are tied with pneumonia as the second-most common type of healthcare-associated infection. Catheter-associated UTI occurs because urethral catheters inoculate organisms into the bladder and promote colonization by providing a surface for bacterial adhesion and thus causing mucosal irritation. Candida spp. accounts for almost 10–15% of the nosocomial UTIs. Patients and methods The study was conducted on 200 catheterized inpatients from ICU. The urine specimens were examined for Candida by using CHROMagar and Integral System Yeasts Plus. Results The API system is highly effective in diagnosing fungal infections. Candida infection was the highest among the age group more than 45 years and in females. The most sensitive antifungal drug for Candida infection was flucytosmine and the least sensitive were nystain and micoconazole. Conclusion There is a strong relationship between host risk factors (old age, antibiotic use, catheterization, female sex, ICU stay, diabetes mellitus, hospitalization) and the expression of various virulence factors of Candida spp. causing candiduria and their resistance to antifungals.

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