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Article Type

Original Study

Abstract

Objective The aim of this work was to evaluate the effect of the use of antibiotic solution formed of lincomycin and gentamycin in normal saline in decreasing the risk for postoperative infection in cases of colorectal cancer. Background Infection after colon cancer operations is still the most common and the most serious complication, with an incidence of more than 30%. Patients and methods This study was carried out on 40 randomly allocated patients with resectable colon and rectal cancer. Group 1 included patients who underwent intra-abdominal lavage with normal saline, followed by a second lavage with a gentamicin–lincomycin solution, and group 2 included those who underwent lavage with normal saline. Results There was a significant difference between groups as regards the presence of postoperative wound sepsis. Isolated organisms were mainly gram negative in both groups. In group 1, the isolated organism was Pseudomonas. In group 2, three cases were diagnosed with Escherichia coli and two cases for each of Pseudomonas, Klebsiella, and Enterobacter. Intraoperative abscess was diagnosed in three cases, two in group 2 and the remaining one in group 1. There was no significant difference between groups as regards the presence of intra-abdominal abscess. Conclusion Antibiotic lavage of the peritoneum is associated with a lower incidence of intra-abdominal abscesses and wound infection. A normal saline lavage did not significantly reduce the number of positive cultures, in contrast to an antibiotic one (gentamicin–lincoamycin), which resulted in negative cultures in 90% of the cases.

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