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Article Type

Original Study

Abstract

Objective The aim of this study was to review the possible role of angiogenesis in the development and/or progression of various endocrinal disorders and its implications. Methods Medline databases and articles available in PubMed, Medscape, and ScienceDirect were searched. The search was performed in 2013, and included all articles with no language restrictions. The initial search presented 150 articles. Among them, ten studies met inclusion criteria. These articles studied the role of angiogenesis in the development and/or progression of various endocrinal disorders and its implications. If the studies did not fulfill inclusion criteria, they were excluded. Study quality assessment included the following – whether ethics approval was gained, had specified eligibility criteria, included appropriate controls, provided adequate information, and defined assessment measures. There was heterogeneity in the collected data, and thus it was not possible to perform a meta-analysis. Significant data were collected, and a structured review was performed. Results The studies review and summarize the role of angiogenesis in the development and/or progression of various endocrinal disorders and its implications. Conclusion We found that the angiogenesis plays an important role in the development and/or progression of various endocrinal disorders, where some endocrinal disorders were characterized or caused by excessive angiogenesis, whereas others were characterized or caused by insufficient angiogenesis. Angiogenesis in endocrinology is a new therapeutic target.

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