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Article Type

Original Study

Abstract

Objectives The aim of this study was to detect a relation between serum levels of interleukin-22 (IL-22) in patients with psoriasis and also to detect a relation of IL-22 with psoriasis area and severity index (PASI). Background IL-22 is highly expressed in several different chronic inflammatory conditions, including psoriasis, inflammatory bowel disease, and rheumatoid arthritis. The best studied function for IL-22 is within the skin, as it has an inflammatory role during skin inflammation. Materials and methods The study was conducted on 40 patients with psoriasis and 20 age-matched and sex-matched healthy individuals. All patients were subjected to history taking and complete medical examination. Serum levels of IL-22 were measured by enzyme-linked immunosorbent assay technique. Serum levels of IL-22 were statistically analyzed in relation to PASI. Results The serum levels of IL-22 were highly elevated in patients with psoriasis compared with healthy people (P < 0.001). The serum IL-22 was significantly higher in patients with severe psoriasis as compared with those with mild and moderate psoriasis. The serum levels of IL-22 were significantly higher in patients with psoriasis experiencing itching as compared with those not experiencing itching (P < 0.001). There was no statistically significant difference between the serum levels of IL-22 and smoking. Conclusion The significant elevation in the serum level of IL-22 in patients with psoriasis when compared with that of healthy controls and the significant elevation in the serum levels of IL-22 with advanced PASI score are suggestive of IL-22 playing a fundamental role in pathogenesis of psoriasis.

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