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Article Type

Original Study

Abstract

Objectives The objective of this study was early detection of attention deficit hyperactivity disorder (ADHD) and/or epilepsy by oxidative stress biomarkers. Background ADHD is a developmental disorder with an etiopathology not fully understood. According to the prevailing view, oxidative metabolism may be involved. Patients and methods The study sample consisted of 100 children. Children were equally divided into four groups (25 children/group): group I (control group); group II (ADHD group); group III (epilepsy group); and group IV (ADHD with epilepsy group). Each participant was subjected to a multidisciplinary clinical interview using a comprehensively devised semistructured sheet covering sociodemographics, psychiatric and pediatric history, and physical examination. Patients were diagnosed with ADHD according to Diagnostic and Statistical Manual of Mental Disorders, 4th ed. criteria. Venous blood samples were collected from all groups; serum malondialdehyde and glutathione S transferase levels were assessed. Results The mean value of serum malondialdehyde was significantly increased in the ADHD group, epilepsy group, and ADHD with epilepsy group when compared with the corresponding mean value in the control group. The mean value of serum glutathione S transferase was significantly decreased in the ADHD group, epilepsy group, and ADHD with epilepsy group when compared with the corresponding mean value in the control group. Conclusion Our study points out that changes in oxidative metabolism may have a role in the pathophysiology of ADHD and epilepsy.

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