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Article Type

Original Study

Abstract

Objective: The aim of the study was to assess the value of the serum concentrations of myoglobin and human heart-type fatty acid binding protein (H-FABP) in the early detection of acute myocardial infarction (AMI). Background: Myoglobin and H-FABP are useful as biochemical markers of muscle injury. We conducted this investigation to detect whether both markers and their ratio were useful in the early detection of AMI. Patients and methods: This study included 21 patients with AMI, 20 patients with skeletal muscle injury, and 10 normal healthy individuals. Their blood samples were obtained (within 6 h of onset of chest pain in AMI patients), and serum concentrations of creatinine, aspartate aminotransferase, H-FABP, myoglobin, cardiac troponin I, and creatine kinase-MB (CK-MB) were determined. Results: It was found that H-FABP has higher sensitivity and predictive accuracy compared with myoglobin in the early detection of AMI: the sensitivity of H-FABP was 95% and that of myoglobin was 81%, and the sensitivity of their ratio was 90%. H-FABP is a more sensitive marker, but in our study its specificity was 90%, which was lower than that of myoglobin (99%) for the detection of AMI within 6 h after the onset of chest pain. Also, our study showed that myoglobin and H-FABP were directly proportional to troponin and CK-MB, in which there is significant positive correlation. Conclusion: The diagnostic sensitivity of H-FABP is high, above that of myoglobin in patients presenting within 6 h of chest pain. H-FABP is a sensitive and specific marker for the early diagnosis of AMI. The lower specificity of H-FABP makes troponin and CK-MB superior for the diagnosis of AMI.

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