Contribution of the STAT4 gene single nucleotide polymorphism to systemic lupus erythematosus

Authors

Ahmed S. Hasab El-Naby, Tanta UniversityFollow
Dalia F. Mohamed, Ain Shams University
Maha A. El Bassuonia, Menoufiya University
Wafaa M. Radwana, Menoufiya University

Article Type

Original Study

Abstract

Objectives: We investigated the prevalence of the STAT4 G > C (rs7582694) polymorphism in patients with systemic lupus erythematosus (SLE) and controls in a sample of the Egyptian population. Background: STAT4 has been found to be a susceptible gene in the development of SLE in various populations. Participants and methods: The presence of the STAT4 G>C (rs7582694) polymorphism was determined by PCR-RFLP. Results: There was an insignificant difference between SLE patients and controls in their phenotypes (P> 0.05). Also, the distribution of the polymorphism among the SLE patients in terms of different symptoms and the anti-dsDNA titer showed an insignificant difference (P> 0.05). Conclusion: There is no association between the STAT4 G>C (rs7582694) polymorphism and susceptibility for SLE in the population of Egypt that may be different from other populations in geographic location, together with the racial and ethnic differences, and also environmental factors, with differences in lifestyle.

Recommended Citation

Hasab El-Naby, Ahmed S.; Mohamed, Dalia F.; El Bassuonia, Maha A.; and Radwana, Wafaa M. (2016) "Contribution of the STAT4 gene single nucleotide polymorphism to systemic lupus erythematosus," Menoufia Medical Journal: Vol. 29: Iss. 2, Article 31.
DOI: https://doi.org/10.4103/1110-2098.192430