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Article Type

Original Study

Abstract

Objectives: The aim of this study was to evaluate the effect of omega-3 supplementation on the lipid profile and inflammatory markers in children on chronic hemodialysis. Background: Children with end-stage renal disease on hemodialysis are at a high risk of adverse cardiovascular events. Dyslipidemia is an important risk factor for cardiovascular morbidity and mortality in dialysis patients, Patients who are on hemodialysis have elevated serum levels of inflammatory markers. There is a growing interest in the application of omega-3 fatty acids in the prevention of cardiovascular disorders in dialysis patients. Omega-3 fatty acids have been postulated to reduce proinflammatory response, confer antithrombotic properties, improve lipid levels (particularly triglycerides), and improve endothelial function. Materials and methods: This clinical trial was conducted in 23 children with end-stage renal disease undergoing dialysis in the pediatric hemodialysis unit of Menoufia University Hospitals. The patients received 1 g omega 3 per day for 3 months. Blood samples were obtained from the patients studied before and at the end of the study for hemoglobin, ferritin, triglyceride, total cholesterol, LDL-c and HDL-c, and high specific-C-reactive protein measurement, and the differences were analyzed. Results: Of 23 patients, 12 were males and 11 were females, mean age 14.52 (8–18) years. There were statistically highly significant differences between the level of triglycerides before (148.86 ± 44.41 mg/dl), and after supplementation with omega-3 fatty acid (135.17 ± 45.99 mg/dl) (P<0.001). The differences found in hemoglobin, parathyroid hormone, ferritin, C-reactive protein, LDL-c, and HDL-c before and after supplementation with omega-3 fatty acid were not statistically significant (P> 0.05). Conclusion: The use of omega 3 led to a significant decrease in serum levels of triglycerides in children on hemodialysis, and its use may be recommended in such patients.

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