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Article Type

Original Study

Abstract

Background Coronary artery disease (CAD) is a complex disease with well-documented genetic and environmental components. Lipoprotein lipase (LPL) is considered a potential target as the variations in the LPL gene have been implicated in a number of pathophysiologic conditions associated with CAD. Objectives The aims of this study were to determine the relationship between LPL gene polymorphisms (PvuII and S447X) and lipid profiles in patients with CAD, and to determine its role in the prediction of the severity of coronary atherosclerosis. Patients and methods A total of 100 individuals were classified by coronary angiography: 80 patients with CAD and 20 controls (normal coronary angiography). Clinical data, carotid sonography, blood lipid profiles, and LPL genotyping for PvuII and S447X using PCR-RFLP were assessed. Results Plasma lipid profiles and carotid intima-media thickness were significantly increased in CAD patients compared with controls. LPL polymorphisms were distributed for PvuII genotypes and alleles in CAD patients versus controls as follows: CC (2.5 vs. 15%), CT (76.25 vs. 75%), and TT (21.25 vs. 10.0%) genotypes; T (59.4 vs. 47.5%) and C (40.6 vs. 52.5%) alleles. LPL S447X genotypes and alleles showed no significant difference between CAD and controls. CT genotypes of LPL PvuII were the highest in number and percentage compared with CC and TT among the CAD patients (P<0.05). However, there was a significant decrease in the systolic and diastolic velocity in CC versus CG genotypes of S447X among CAD patients (P < 0.05). Other carotid ultrasound, lipid profiles, or coronary angiography parameters were not significant in both genotypes of LPL among CAD patients. Conclusion Atherosclerotic ischemic patients showed a higher association in the number and percent of CT genotypes of PvuII LPL that may be an important diagnostic risk biomarker and may implicate a therapeutic intervention in CAD.

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