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Article Type

Original Study

Abstract

Objective The aim of the study was to compare the effect of permeability of low-flux versus high-flux dialysis membranes on control of metabolic abnormalities in chronic hemodialysis patients. Background End-stage renal disease is associated with multiple physiological and metabolic disturbances, including hypertension, anemia, hyperparathyroidism, dyslipidemia, malnutrition, and other serious problems that markedly and negatively affect prognosis and the quality of life of uremic patients. New dialyzers have large pores and they are more compatible than pure cellulose membranes; thus, they provoke less inflammatory reaction and are more efficient in removal of uremic toxins. Materials and methods Forty adult patients on regular hemodialysis were enrolled in a prospective study. Low-flux polysulfone membranes were used for at least 6 months and then patients were switched to use high-flux polysulfone membranes for 1 month. Serum electrolytes and intact parathyroid hormone (PTH) before and after dialysis were compared before and after changes in dialysis membrane. Results At the end of the 1-month use of high-flux filters, a highly significant increase in the mean of hemoglobin levels from 9.50 ± 1.08 to 10.29 ± 1.04 (P = 0.001) was evident. Postdialysis mean arterial blood pressure decreased significantly after use of high-flux dialysis (P = 0.002). There were highly significant decreases in predialysis blood urea nitrogen, phosphorus, sodium, and potassium after the use of high-flux filters. Predialysis intact PTH level (415.96 ± 226.72 ng/dl) showed a significant decline (P < 0.05) compared with the predialysis intact PTH (312.28 ± 191.98 ng/dl) with low-flux membranes. Conclusion High-flux dialysis membranes are more efficient in control of metabolic abnormalities in chronic hemodialysis patients than low-flux membranes.

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