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Article Type

Original Study

Abstract

Objective The aim of this study was to evaluate the association between interleukin (IL)-1β −31T/C and matrix metalloproteinase 3 (MMP3) −1171 single-nucleotide polymorphisms and the susceptibility of hepatocellular carcinoma (HCC) patients. Background IL-1β is an important cytokine. IL-1β −31T/C polymorphism located in the promoter region of IL-1β has been linked to an elevated risk of HCC. MMP3 is a MMP that has proteolytic activity. MMP3 polymorphism at 1171 has been linked to an elevated risk and a highly invasive type of HCC. Patients and methods This study included 30 HCC patients, 30 hepatitis C virus (HCV) patients, and 20 healthy controls. IL-1β and MMP3 polymorphisms were genotyped using the restriction fragment length polymorphism discrimination assay technique. Results Data revealed that the frequency of IL-1β C/T and MMP3 5A/6A polymorphisms were higher in patient groups (HCC and HCV) compared with healthy controls. Our results indicated a significant association between IL-1β C/T polymorphism and HCC susceptibility; also, a significant association was detected between MMP3 5A/6A polymorphism and HCC susceptibility. Conclusion These results suggested that IL-1β C/T and MMP3 5A/6A polymorphisms are associated with an increased risk of developing HCC in Egyptian patients.

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