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Article Type

Original Study

Abstract

Objective To shed light on the role of mesenchymal stem cells (MSCs) in keloid pathogenesis. Background Keloids are fibroproliferative scars that show a benign yet quasineoplastic behavior and morphology, as evidenced by high recurrence and aggressive invasion into the surrounding skin. MSC populations originate from bone marrow (BM) stroma, which can give rise to stromal mature mesenchymal cells and aid regeneration of the BM microenvironment. Human BM-derived MSCs may contribute toward keloid pathogenesis. Patients and methods A total of 30 skin biopsy specimens from keloid lesions were used and 15 healthy volunteers were used as a control. Histopathological examination of hematoxylin and eosin-stained sections of keloid was carried out for the evaluation of histopathological parameters. The expression of CD29 was examined immunohistochemically. Results There were statistically significant differences between CD29 immunostaining in normal skin and lesional area of keloid in favor of keloid. There were no significant differences between different epidermal intensities of CD29 expression in keloid. Conclusion MSCs may share in keloid pathogenesis. The future therapy of keloid scars may have to target MSC differentially in order to deprive these tumors of their regenerative cell pools. This may represent an innovative method for keloid treatment.

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