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Subject Area

Pediatrics

Article Type

Original Study

Abstract

Objectives: To assess the serum copeptin levels in children with Sickle cell anemia. Background: Sickle cell anemia (SCA) is one of the most common hereditary diseases in the world. Copeptin is the C-terminal part of the prohormone for provasopressin and seems clinically relevant in various clinical conditions. Methods: This is a case control study conducted on 62 subjects, 31 pediatric patients with Sickle cell anemia and 31 healthy children, all aged 1 year to 18 to assess the serum copeptin levels in children with Sickle cell anemia. Who attended pediatric hematology clinics of the Menoufia university hospitals, during a period time from April 2021 to September 2022. All cases were subjected to detailed history, clinical examination, anthropometric measurement, radiological and laboratory investigations including serum copeptin levels. Results: Serum copeptin level was significantly increased among case group (5.02±4.30 ng/ml) than control group (2.79±1.21 ng/ml) with p value 0.007. Also, serum copeptin level was increased in direct relation with prevalence of complications among case groups, (p

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