Lateralizing Ability of Magnetic Resonance Spectroscopy and Diffusion Tensor imaging in Temporal Lobe Epilepsy

Authors

Rasha Ali El-Kapany, Department of Neuro Psychiatry, Faculty of Medicine, Menoufia University, shibinElkom, Menoufia, Egypt
Ibrahim Al-Sayed Al-Ahmar, Department of Neuro Psychiatry, Faculty of Medicine ,Menoufia University, shibinElkom, Menoufia, Egypt
Mona Sabry Elkholy, Department of Neuro Psychiatry, Faculty of Medicine ,Menoufia University, shibinElkom, Menoufia, Egypt
Rasha Abdelhafiz Aly, Department of Neuro Psychiatry, Faculty of Medicine, Menoufia University, shibinElkom, Menoufia, Egypt
Ahmed Ali Saad Ali Hassan, Department of Radiology, National Liver Institute. Menoufia University, Elbagor ,Menoufia, EgyptFollow

Subject Area

Neurology

Article Type

Original Study

Abstract

Background: Temporal lobe epilepsy (TLE) is the most common type of intractable and partial epilepsies. The only standard treatment for seizure-free status with manifest TLE is surgical which includes amygdala-hippocampectomy. The majority of temporal lobe seizures originate in the mesial temporal structures, primarily in the hippocampus, para hippocampal gyrus and amygdala.

Objectives: To compare lateralizing ability of Magnetic resonance spectroscopy and Diffusion tensor imaging in patients with temporal lobe epilepsy.

Methods: The study recruited 50 participant assigned into two groups: the first group included 25 epileptic cases and the second group included 25normal controls. Age showed a mean ± SD of 24.22 ± 9.7 years. All participants subjected to the following, clinical assessment, EEG, radiological assessment including: MRI epilepsy protocol, MRS and DTI. Data were collected, revised, then extracted and coded in excel file.

Results: MR spectroscopy has demonstrated consistent metabolic abnormalities in partial seizures. Semiology showed the highest and the most perfect diagnostic ability indices for epilepsy (100%), followed by MRS (accuracy = 92%), and DTI difference ≥ 0.014 (accuracy = 86%).

Conclusion:

Semiology showed the highest and the most perfect diagnostic ability indices for epilepsy (100%).

MR Spectroscopy is a highly sensitive tool to predict the TLE (accuracy = 92%).

DTI difference ≥ 0.014 (accuracy = 86%) so it has high value also in diagnosis of temporal lobe epilepsy.

Recommended Citation

El-Kapany, Rasha Ali; Al-Ahmar, Ibrahim Al-Sayed; Elkholy, Mona Sabry; Aly, Rasha Abdelhafiz; and Hassan, Ahmed Ali Saad Ali (2023) "Lateralizing Ability of Magnetic Resonance Spectroscopy and Diffusion Tensor imaging in Temporal Lobe Epilepsy," Menoufia Medical Journal: Vol. 36: Iss. 1, Article 12.
DOI: https://doi.org/10.59204/2314-6788.1011