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Subject Area

Internal Medicine

Article Type

Original Study

Abstract

Objective To assess the relation between plasma nesfatin-1 levels and grades of diabetic nephropathy. Background Nesfatin-1 may be involved in the pathogenesis of diabetic kidney disease. Our study aimed to determine the relationship of nesfatin-1 levels with different grades of diabetic nephropathy in type 2 diabetic patients and to detect the possible association of nesfatin-1 with some metabolic parameters in such diabetic patients. Patienta and methods The study enrolled 120 age-matched patients selected from the outpatient clinic, Alexandria Police Hospital. Patients were divided into four groups: group I included 30 diabetic patients without albuminuria, group II included 30 diabetic patients with low-grade albuminuria 30–300 mg/dl, group III included 30 diabetic patients with high-grade albuminuria more than 300 mg/dl, and group VI included 30 nondiabetic healthy control groups. All patient groups were subjected to laboratory investigations, which included glycosylayed hemoglobin; kidney function tests including blood urea nitrogen and serum creatinine levels, urinary albumin to creatinine ratio; determination of serum nesfatin-1 levels; and correlation between serum nesfatin-1 and different parameters. Results There was no statistically significant difference in nesfatin-1 level among the four groups. There were no significant correlations between plasma nesfatin-1 and serum creatinine, urine albumin–creatinine ratio, and glycosylated hemoglobin. Conclusion There is no correlation between plasma nefatin-1 level and the grades of diabetic kidney disease. So, plasma nesfatin-1 is not considered for the prediction of developing diabetic kidney disease in previously unaffected patients with diabetes mellitus.

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