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Subject Area

Dermatology

Article Type

Original Study

Abstract

Objective The aim was to assess serum magnesium level in patients with liver cirrhosis. Background Cirrhosis is a chronic disease of the liver in which diffuse destruction and regeneration of hepatic parenchymal cells and diffuse increase in connective tissue result in disorganization of the lobular architecture. Micronutrients play a significant role in liver diseases. Patients and methods A case–control study was conducted on 60 patients with liver cirrhosis who were classified into the following groups. Group I included 60 patients with liver cirrhosis. They were classified according to the Child-Pugh class into: group Ia which included 20 Child-Pugh A cirrhotic patients; group Ib included 20 Child-Pugh B cirrhotic patients; and group Ic included 20 Child-Pugh C cirrhotic patients. Group II included 20 healthy participants as a control group. Patients and controls were selected from the inpatient and outpatient clinic of the Hepatology Department Damanhur Fever Hospital and Tropical Department of Menoufia University. Routine investigations, magnesium, potassium, and sodium levels were investigated. Results Sodium, potassium, and magnesium levels were decreased than the normal range among cirrhotic patients and the lowest mean value was 122.950 ± 2.502, 4.165 ± 0.503, and 1.277 ± 0.202, respectively, among cirrhotic patients (Child class C). Conclusion Trace element abnormalities may reflect the condition of liver dysfunction. Liver dysfunction may alter the metabolism of trace elements. Does correction of these metabolic abnormalities of trace elements delay or prevent complication of cirrhosis should be evaluated in upcoming studies.

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