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Subject Area

Neuropsychiatry

Article Type

Original Study

Abstract

Objective To evaluate the mean platelet volume (MPV) and its correlation with cardiovascular risk in type 2 diabetic patients. Background Platelet functions have important roles in the development of vascular complications in diabetic patients. Platelets with increased volume have increased activity compared to smaller ones, therefore, MPV is used as a marker for platelet activity. Patients and methods A cross-sectional analytical study was done on a group of 60 type 2 diabetic patients divided into group I, included 23 cases without cardiovascular disease, group II, included 37 cases with cardiovascular disease, and group III, included 20 healthy people as the control group. All patients attended the Endocrine and Diabetes Clinic in Menoufia University during the period from 2015 to 2016. Comparisons of fasting blood sugar, 2-h post prandial (2HPP), lipid profile, and MPV were tested. Results Diabetic patients with cardiovascular disease had a higher MPV (11.08 ± 1.39) than diabetic patients without cardiovascular disease (10.53 ± 1.33) and healthy group (8.30 ± 1.62). There was a significant difference between the studied groups regarding MPV, fasting blood sugar, 2HPP and low density lipoprotein cholesterol, and hemoglobin A1c. In addition, MPV showed a significant positive correlation with fasting blood sugar, 2HPP, hemoglobin A1c, serum cholesterol, and low density lipoprotein cholesterol. Whereas, MPV was not correlated with serum glyceride and high-density lipoprotein cholesterol. Conclusion Platelet dysfunction occurs in diabetic patients and this is demonstrated by higher than normal MPV. MPV was found to carry a risk of development of cardiovascular disease in these patients.

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