Subject Area
Obstetrics and Gynecology
Article Type
Original Study
Abstract
Objective The aim of the paper was to investigate the relationship between serum YKL-40 levels and severity of chronic obstructive pulmonary disease (COPD). Background COPD is a major health problem with increasing morbidity and mortality throughout the world. A newly recognized biomarker, YKL-40, is a chitin-binding glycoprotein, and its serum level is elevated in inflammatory diseases. However, it has not been thoroughly investigated in COPD. Patients and methods A total of 30 patients with stable COPD and 10 healthy individuals as a control group were enrolled for estimation of modified Medical Research Counseling dyspnea scale, spirometry, and serum YKL-40 levels. Results Serum YKL-40 level was increased significantly in patients with COPD compared with healthy controls. There was a positive correlation between serum YKL-40 level and each of modified Medical Research Counseling dyspnea scale severity and age, and a negative correlation with forced expiratory volume in the first second percent of predicted. Conclusion High serum YKL-40 levels were correlated with severity of COPD.
Recommended Citation
Khames, Ahmed A.; Fouda, Doaa S.; El Madbouh, Ibrahim S.; Yousif, Maha; and Azab, Nourane Y.
(2019)
"Study of serum YKL-40 level in patients with chronic obstructive pulmonary disease,"
Menoufia Medical Journal: Vol. 32:
Iss.
1, Article 31.
DOI: https://doi.org/10.4103/mmj.mmj_68_17
Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
