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Subject Area

General Surgery

Article Type

Original Study

Abstract

Objective The aim of this study was to evaluate serum pentraxin-3 (PTX3) levels as an indicator of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Background DR is responsible for 10.2% of worldwide visual loss. Pentraxin-3 is an acute phase protein secreted by different types of cells and correlates with the disease activity. Patients and methods A total of 80 individuals were included in the study. They were divided into three groups. Group 1 included 30, type 2 diabetic patients without retinopathy, group 2 included 30, type 2 diabetic patients with retinopathy, and group 3 included 20 apparently healthy individuals. Group 2 was subdivided into 20 patients with nonproliferative and 10 patients with proliferative DR. Serum glycated hemoglobin, C-reactive protein (CRP), lipid profile, liver function tests, renal function tests, serum PTX3 level, and fundus examination were measured in all the patients. Results Serum PTX3 was significantly elevated in T2DM with retinopathy than T2DM without retinopathy and control group. There is no statistical difference between proliferative and nonproliferative DR regarding PTX3. Serum PTX3 was significantly positively correlated with age and high-sensitivity CRP in the proliferative DR group and cholesterol, low-density lipoprotein and high-sensitivity CRP in the proliferative DR group. Conclusion PTX3 levels were significantly higher in T2DM with retinopathy than those without retinopathy and control group, and positively correlated with inflammatory marker. Thus, it might be used in the prognosis of DR.

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